Diaprel, comprimate

Prospect

Compozitie
Cutie cu 30 comprimate divizibile a 80 mg gliclazid (DCI).

Actiune terapeutica
Diaprelul este o sulfamida hipoglicemianta care poseda o dubla polaritate de actiune: proprietatile metabolice insotesc proprietatile hemovasculare originale.
Proprietati metabolice: Diaprelul este insulinosecretor si potenteaza efectul insulinosecretor al glucozei. El creste raspunsul pancreatic, stimuland celulele b ale pancreasului si determina un raspuns insulinic precoce, la ingestia alimentara. In plus, Diaprelul amelioreaza actiunea insulinei la nivelul ficatului si muschiului.
Diaprel diminueaza nivelul de colesterol si trigliceride plasmatice la diabetici.
Proprietati hemovasculare: Diaprel reduce adezivitatea si agregarea plachetara, micsorand turn-overul trombocitelor si normalizeaza activitatea fibrinolitica endoteliala in toate formele de diabet insulino si non-insulinodependent. La pacientii cu retinopatie diabetica, aceste proprietati pot intarzia evolutia retinopatiei.

Indicatii

Diaprelul se adreseaza diabeticilor care necesita tratament antidiabetic oral: diabet non-acidocetozic, noninsulino-dependent al adultului si al varstnicului, daca regimul prescris nu este suficient pentru a restabili echilibrul glucidic.

Mod de administrare

In toate formele de diabet neechilibrate prin regimul prescris. In majoritatea cazurilor, posologia este de 2 comprimate (160 mg) pe zi, in doua prize (dimineata si seara) in timpul meselor. In formele usoare, posologia este de 1 comprimat (80 mg) pe zi, in cazurile mai severe, doza poate fi crescuta pana la 4 comprimate (320 mg) pe zi, in doua prize.
Prescriptia poate fi progresiva si prudenta: in primele zile ale tratamentului, se va supraveghea glicemia a jeun, postprandiala si glicozuria pentru 24 ore.

Contraindicatii
Diabet infantil, diabet juvenil; cetoza grava, acidoza; precoma si coma diabetica; insuficienta renala severa; insuficienta hepatica grava; antecedente alergice cunoscute sulfamidelor; asocierea cu miconazol (cale orala si injectabila); sarcina si alaptare.

Reactii adverse
O eruptie cutanata benigna sau un prurit moderat poate surveni in mod exceptional la pacientii cu intoleranta la sulfoniluree. Ca si alte produse din aceasta grupa terapeutica, actiunea hipoglicemianta poate sa potenteze administrarea simultana a altor medicamente: anticoagulante, cumarinice, fenilbutazona si derivati, salicilati, beta-blocanti, probenecid, sulfamide antibacteriene de lunga durata. Accidente toxice sanguine nu au fost relatate pana in prezent, dar pot fi intalnite ca si in cazul altor sulfamide. Manifestarile hipoglicemiante sunt exceptionale si nu s-a semnalat nici un caz de coma.

Precautii
Utilizarea Diaprelului nu implica renuntarea la respectarea regimului hipocaloric si/sau hipoglucidic. Controalele biologice obisnuite la diabetici (glicemia a jeun si postprandiala, glicozuria pentru 24 ore) trebuie efectuate cu regularitate. In caz de interventie chirurgicala sau alte cauze de decompensare a diabetului, trebuie intrevazuta posibilitatea apelarii la insulina
Medicamente care potenteaza efectul hipoglicemiant al Diaprelului: miconazol, antiinflamatoare nesteroidiene, sulfamide antibacteriene, cumarinice, IMAO, -blocanti, diazepam, tetraciclina, maleat de perhexilina, cloramfenicol, clofibrat. Ingestia de alcool etilic poate, de asemenea, sa potenteze efectul hipoglicemiant. Barbituricele pot reduce activitatea hipoglicemianta a Diaprel, si alte produse (corticoizi, salidiuretice, estroprogestative) sunt susceptibile de a modifica echilibrul glicemic, in sensul unei hiperglicemii.

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AMVC Error

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File /usr/share/pear/AS/SMARTY/Smarty.class.php at 1092


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