Ciprofloxacin, comprimate filmate

Prospect

Compozitie
Un comprimat filmat contine 500 mg ciprofloxacin clorhidrat monohidrat si excipienti: amidon de porumb, celuloza microcristalina, glicolat de sodiu si amidon, stearat de magneziu, dioxid de siliciu coloidal, hipomeloza, macrogol 4000, dioxid de titan E171.

Actiune terapeutica
ciprofloxacinul este o fluorochinolona cu puternica actiune bactericida si spectru larg de actiune. Actiunea bactericida se datoreaza perturbarii sintezei de adn bacterian prin inhibarea adn-ului girazei (topoizomeraza), enzima care catalizeaza procesul de condensare a catenelor dublu elicoidale de adn in timpul diviziunii, astfel incat acestea sa incapa in celula. Impiedicarea supraspiralarii (care urmeaza desfacerii lanturilor de adn) face imposibila segregarea normala a cromozomilor si plasmidelor, determinand oprirea diviziunii si moartea microorganismelor sensibile.

Indicatii
Se recomanda in tratamentul infectiilor cu tulpini sensibile la ciprofloxacin: escherichia coli, klebsiella pneumoniae, Enterobacter cloacea, Proteus mirabilis, Proteus vulgaris, Providencia stuastii, Providencis rettergi, Morganella morganii, Citrobacter freundii, Psudomonas aeruginosa, Staphilococcus pyogenes, Streptococcus faecalis, Serratia marcescens.
Se utilizeaza in: infectii ale tractului respirator inferior, infectii osteoarticulare si infectii urinare.

Mod de administrare

In infectiile severe ale tractului urinar superior si inferior, infectiile tractului respirator inferior, si infectiile osoase si articulare doza recomandata este de 1-2 comprimate de 2 ori pe zi (la 12 ore interval). Stabilirea dozei administrate se face in functie de severitatea afectiunii. Durata uzuala a tratamentului este de 7 - 14 zile pentru infectiile necomplicate. Ea trebuie prelungita cu inca 2 zile dupa disparitia semnelor si simptomelor infectiei. In infectiile osoase si articulare tratamentul dureaza 4-6 saptamani. Pacientii cu tulburari ale functiei renale nu necesita modificarea dozelor de Ciprofloxacin, atata timp cat clearance-ul creatininei nu este egal sau mai mic cu 20 ml/min. Cand disfunctia renala este severa, doza zilnica uzuala de ciprofloxacin trebuie scazuta.

Contraindicatii

Medicamentul este contraindicat la persoanele cu alergie in antecedente la ciprofloxacina sau alte chinolone.

Precautii
Ca si celelalte chinolone, ciprofloxacinul poate determina stimularea sistemului nervos central manifestata prin tremor, astenie, fotofobie, confuzii si foarte rar halucinatii sau convulsii. De aceea, se utilizeaza cu prudenta la pacientii suspectati sau cunoscuti ca avand tulburari ale sistemului nervos central, ateroscleroza severa, epilepsie sau conditii predispozante pentru convulsii. Utilizarea ciprofloxacinei poate determina cristalurie, daca urina are pH alcalin. In consecinta este necesara o hidratare adecvata si evitarea alcalinizarii urinei. Doza zilnica nu trebuie depasita. La pacientii cu afectari ale functiei renale poate fi necesara adaptarea dozei. Nu se recomanda tratamentul cu ciprofloxacin la copii in perioada de crestere, decat in cazuri exceptionale de infectii grave cu germeni rezistenti la alte antibiotice.

Sarcina si alaptare

Ca si celelalte medicamente incluse in aceasta clasa, ciprofloxacin cauzeaza artropatii la animale imature, de aceea utilizarea lor in cursul sarcinii este contraindicata. alaptarea: ciprofloxacinul se excreta in laptele matern. Daca tratamentul este absolut necesar, se intrerupe alaptarea.

Reactii adverse
Ciprofloxacinul este in general un medicament bine tolerat. Totusi, se mentioneaza pentru un numar redus de cazuri aparitia de tulburari gastro-intestinale, afectiuni ale pielii, ale sistemului muscular (tendinita achiliana, care poate evolua spre ruptura de tendon) si ale sistemului nervos central.

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AMVC Error

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File /usr/share/pear/AS/SMARTY/Smarty.class.php at 1092


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