Anemie pernicioasa

Anemie rezultand dintr-o proasta absorbtie a vitaminei B12 in stomac. Boala lui Biermer se intalneste mai ales in a doua jumatate a existentei.

Cauze - Aceasta este o boala autoimuna cauzata de distrugerea celulelor gastrice care secreta acidul clorhidric si factorul intrinsec, absenta celui din urma provocand o proasta absorbtie a vitaminei B12. In afara rolului sau in sistemul nervos, vitamina B12 este indispensabila sintezei ADN-ului, absenta sa are consecinte importante, indeosebi asupra vietii tesuturilor in diviziune celulara rapida, ca maduva osoasa, si antreneaza o diminuare a numarului polinuclearelor neutrofile (globule albe care intervin in lupta impotriva infectiilor) si a plachetelor, precum si aparitia de megaloblaste (globule rosii de marime mai mare decat cea normala).

Simptome si diagnostic - Simptomele sunt acelea ale oricarei anemii: paloare, astenie, dispnee. Diagnosticul se stabileste prin mielograma (examenul celulelor maduvei osoase), care pune in evidenta o anemie megaloblastica cu un nivel scazut de vitamina B12 in sange, in timp ce nivelul acidului folic (alta vitamina susceptibila sa explice o anemie megaloblastica) este normal. Absenta acidului clorhidric si a factorului intrinsec in stomac este pusa in evidenta fie prin dozare directa in lichidul gastric prelevat prin tubaj, fie prin testul lui Schilling.

Tratament - Se bazeaza pe injectarea de vitamina B12 pe cale intramusculara pana la corectarea anemiei, apoi o data pe luna pentru tot restul vietii. Este prudent ca mucoasa gastrica sa fie supravegheata prin fibroscopie efectuata din doi in doi ani, boala putand favoriza aparitia unor polipi susceptibili sa degenereze.

Sinonime: Biermer (boala a lui), Biermer (anemie a lui), boala a lui Addillon-Biermer.

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AMVC Error

Smarty error: unable to read resource: "/var/www/html/sfatulmedicului.ro/external/templates/default//adds/box_.tpl"

File /usr/share/pear/AS/SMARTY/Smarty.class.php at 1092


Debug trace:
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